Sponsored Asset

Enhanced mAb Aggregate Removal with Mixed-Mode Chromatography

Explore an efficient tool for simultaneous aggregate and HCP removal
Sept. 24, 2025
Sponsored by
Monoclonal antibodies (mAbs) are powerful therapeutics that are clinically trusted and well-characterized. However, their production can be complicated by difficult-to-remove aggregates and impurities.
In this application note, you’ll learn more about how a mixed-mode chromatography tool designed to tackle high-aggregate challenges in mAb purification resulted in:
  • High monomer purity from 10% aggregate level feedstock
  • The removal of difficult host cell proteins (HCPs)
  • Increased productivity via flow-through operation (over bind-and-elute methods)
  • Expanded toolkit of mAb polish chromatography resins
Discover how you may enhance downstream mAb processes with guidance from this application note.

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